ACD Antibody | CSB-PA839289LA01HU

ACD Antibody | CSB-PA839289LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: ACD

Aliases: Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein), ACD, PIP1 PTOP TINT1 TPP1

Background: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q96AP0

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Recombinant Human Adrenocortical dysplasia protein homolog protein (328-497AA)

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB; Recommended dilution: WB:1:500-1:5000

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:5000

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling;Cell biology