ZFP36 Antibody, Biotin conjugated | CSB-PA026448LD01HU

ZFP36 Antibody, Biotin conjugated | CSB-PA026448LD01HU | Cusabio

ZFP36 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: ZFP36

Aliases: mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36), ZFP36, G0S24 NUP475 RNF162A TIS11A TTP

Background: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE) -containing mRNA transcripts by promoting their poly (A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:9703499, PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:27193233, PubMed:23644599, PubMed:25815583) . Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599) . Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599) . Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915) . Self regulates by destabilizing its own mRNA (PubMed:15187101) . Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:19188452, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:25815583) . Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF) -alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN) - and/or lipopolysaccharide (LPS) -induced macrophages (By similarity) . Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721) . Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632) . Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity) . Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587) . Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity) . Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721) . Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526) . May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915) . Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404) . In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity) . Negatively regulates nuclear poly (A) -binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity) . Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity) . Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009) . Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077) .

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: P26651

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human mRNA decay activator protein ZFP36 protein (16-103AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Neuroscience

Research Areas: Epigenetics & Nuclear Signaling;Neuroscience;Immunology;Signal transduction