Cusabio Recombinant Antibodies
YY1 Antibody | CSB-RA026297A0HU
- SKU:
- CSB-RA026297A0HU
- Availability:
- 3 to 7 Working Days
Description
YY1 Antibody | CSB-RA026297A0HU | Cusabio
YY1 Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Antibody Type: Recombinant Antibody
Target Names: YY1
Aliases: Transcriptional repressor protein YY1, Delta transcription factor, INO80 complex subunit S, NF-E1, Yin and yang 1, YY-1, YY1, INO80S
Background: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647).
Isotype: Rabbit IgG
Conjugate: Non-conjugated
Clonality: Monoclonal
Clone Number: 3A11
Uniport ID: P25490
Modified: Epigenetics and Nuclear Signaling
species: Human
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human YY1
Tested Applications: ELISA
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.