Cusabio Recombinant Antibodies
XPO1 Antibody | CSB-RA930964A0HU
- SKU:
- CSB-RA930964A0HU
- Availability:
- 3 to 7 Working Days
Description
XPO1 Antibody | CSB-RA930964A0HU | Cusabio
XPO1 Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Antibody Type: Recombinant
Target Names: XPO1
Aliases: Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog), XPO1, CRM1
Background: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Isotype: Rabbit IgG
Conjugate: Non-conjugated
Clonality: Monoclonal
Clone Number: 9F2
Uniport ID: O14980
Modified: Epigenetics and Nuclear Signaling; Signal transduction
species: Homo sapiens (Human)
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human CRM1
Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:50-1:200
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.