vpx Antibody | CSB-PA356976LA01HLZ

vpx Antibody | CSB-PA356976LA01HLZ | Cusabio

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Product Type: Polyclonal Antibody

Target Names: vpx

Aliases: Protein Vpx (Viral protein X) (X ORF protein), vpx

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P06939

Host Species: Rabbit

Species Reactivity: Human immunodeficiency virus type 2 subtype A

Immunogen: Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-112AA)

Immunogen Species: Human immunodeficiency virus type 2 subtype A

Applications: ELISA, WB

Tested Applications: ELISA, WB; Recommended dilution: WB:1:500-1:5000

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:5000

Dilution Ratio3:

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: N/A

Research Areas: N A