vpx Antibody, Biotin conjugated | CSB-PA323941HD01SHD

vpx Antibody, Biotin conjugated | CSB-PA323941HD01SHD | Cusabio

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Product Type: Polyclonal Antibody

Target Names: vpx

Aliases: Protein Vpx (Viral protein X) (X ORF protein), vpx

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: P19508

Host Species: Rabbit

Species Reactivity: Simian immunodeficiency virus

Immunogen: Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)

Immunogen Species: Simian immunodeficiency virus

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Others

Research Areas: Others