VPS11 Antibody | CSB-PA887959ESR2HU

VPS11 Antibody | CSB-PA887959ESR2HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: VPS11

Aliases: Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108), VPS11, RNF108

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203) . Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203) . Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287) . Involved in the retrograde Shiga toxin transport (PubMed:23593995) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q9H270

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA)

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Purification Method: Antigen Affinity Purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

Dilution Ratio3:

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Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal transduction