TRIM25 Antibody | CSB-PA997812

TRIM25 Antibody | CSB-PA997812 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: TRIM25

Aliases: EFP; Efp; Estrogen responsive finger protein; TRI25; TRIM25

Background: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.

Inoue S., Proc. Natl. Acad. Sci. U.S.A. 90:11117-11121 (1993) .
The MGC Project Team, Genome Res. 14:2121-2127 (2004) .
Rush J., Nat. Biotechnol. 23:94-101 (2005) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q14258

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Synthesized peptide derived from internal of human ZNF147.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:3000

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

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Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Epigenetics & Nuclear Signaling;Cell biology;Signal transduction