TP53 Monoclonal Antibody | CSB-MA989534

TP53 Monoclonal Antibody | CSB-MA989534 | Cusabio

TP53 Monoclonal Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Monoclonal Antibody

Target Name: TP53

Aliases: P53; LFS1; TRP53; TP53

Relevance: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Isotype: IgG2b

Conjugate: Non-conjugated

Clone Number:

Uniport ID: P04637

Alternatives To SCBT:

Host Species: Mouse

Species Reactivity: Human

Immunogen: Purified recombinant human p53 protein fragments expressed in E.coli.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;Recommended dilution:WB:1:500-1:5000

Purification Method: Affinity purified

Dilution Ratio1: WB:1:500-1:5000

Dilution Ratio2:

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Buffer: Purified mouse monoclonal in PBS (pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Epigenetics and Nuclear Signaling;Cancer;Cell biology