TOP2B Antibody | CSB-PA587958

TOP2B Antibody | CSB-PA587958 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: TOP2B

Aliases: DNA topoisomerase II; beta isozyme; EC 5.99.1.3; TP2B; TOP2B

Background: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Ren篓 M. Linka, Nucleic Acids Res., May 2007; 10.1093.
John R. Jenkins, Nucleic Acids Res., Nov 1992; 20: 5587 - 5592.
Kathryn L. Gilroy, Nucleic Acids Res., Mar 2006; 34: 1597 - 1607.
Sophie Dereuddre, Cancer Res., Oct 1997; 57: 4301 - 4308.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q02880

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Synthesized peptide derived from Internal of human topoisomerase II β.

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

Dilution Ratio3: IHC:1:50-1:100

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling;Cancer