Cusabio Polyclonal Antibodies
Tgfb1 Antibody, Biotin conjugated | CSB-PA023446LD01MO
- SKU:
- CSB-PA023446LD01MO
- Availability:
- 3 to 7 Working Days
Description
Tgfb1 Antibody, Biotin conjugated | CSB-PA023446LD01MO | Cusabio
Tgfb1 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Product Type: Polyclonal Antibody
Target Names: Tgfb1
Aliases: Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP) ], Tgfb1
Background: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049) . Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity) .
Isotype: IgG
Conjugate: Biotin
Clonality: Polyclonal
Uniport ID: P04202
Host Species: Rabbit
Species Reactivity: Mouse
Immunogen: Recombinant Mouse Transforming growth factor beta-1 protein (30-278AA)
Immunogen Species: Mouse
Applications: ELISA
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Cardiovascular
Research Areas: Cancer;Cardiovascular;Metabolism;Signal transduction;Stem cells