SUMO1 Antibody | CSB-PA022948KA01HU

SUMO1 Antibody | CSB-PA022948KA01HU | Cusabio

SUMO1 Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: SUMO1

Aliases: SUMO1;DAP1;GMP1;OFC10;PIC1;SENP2;SMT3;SMT3C;SMT3H3; UBL1

Background: Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein family. The covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitination. This post-translational modification is a reversible, multi-step process that is initiated by cleaving a precursor protein to a mature protein. Mature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target protein. Ubiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functions. Ubiquitin predominantly regulates degradation of its target. In contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IκB-α to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stability. SUMO-2/-3 forms poly- (SUMO) chains, is conjugated to topoisomerase II and APP, regulates chromosomal segregation and cellular responses to environmental stress, and plays a role in the progression of Alzheimer disease.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P63165

Host Species: Rabbit

Species Reactivity: Human, Mouse, Rat

Immunogen: A synthetic peptide of human SUMO-1

Immunogen Species: Human

Applications: ELISA, WB, IHC, ICC, IP, FC

Tested Applications: ELISA, WB, IHC, ICC, IP, FC;WB:1:500-1:2000, IHC:1:20-1:200, ICC:1:50-1:200, IP:1:20-1:50, FC:1:20-1:50

Purification Method: Affinity purification

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:2000

Dilution Ratio3: IHC:1:20-1:200

Dilution Ratio4: ICC:1:50-1:200

Dilution Ratio5: IP:1:20-1:50

Dilution Ratio6: FC:1:20-1:50

Buffer: Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Cancer;Cardiovascular;Cell biology;Metabolism