Cusabio Polyclonal Antibodies
SMUG1 Antibody | CSB-PA897931
- SKU:
- CSB-PA897931
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
SMUG1 Antibody | CSB-PA897931 | Cusabio
SMUG1 Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: SMUG1
Aliases: Single-strand selective monofunctional uracil DNA glycosylase; SMUG1;
Background: Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A) . Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU) ] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.
Ide H., Biochemistry 42:5003-5012 (2003) .
Sugano S., Nat. Genet. 36:40-45 (2004) .
Venter J.C., Submitted (JUL-2005) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: Q53HV7
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Synthesized peptide derived from internal of human SMUG1.
Immunogen Species: Human
Applications: ELISA, WB
Tested Applications: ELISA, WB;WB:1:500-1:3000
Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:3000
Dilution Ratio3:
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Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Epigenetics and Nuclear Signaling
Research Areas: Epigenetics & Nuclear Signaling