SIGIRR Antibody | CSB-PA743558ESR1HU

SIGIRR Antibody | CSB-PA743558ESR1HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: SIGIRR

Aliases: Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8), SIGIRR

Background: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q6IA17

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Recombinant Human Single Ig IL-1-related receptor protein (1-120AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Purification Method: Antigen Affinity Purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:1000-1:5000

Dilution Ratio3: IHC:1:20-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Immunology

Research Areas: Immunology;Signal transduction