SESN2 Antibody | CSB-PA021096NA01HU

SESN2 Antibody | CSB-PA021096NA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: SESN2

Aliases: Sestrin-2 (EC 1.11.1.15) (Hypoxia-induced gene), SESN2, Hi95 SEST2

Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190) . Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190) . This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615) . May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085) . May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468) . Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684) . Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503) . However, this could not be confirmed (PubMed:19113821) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P58004

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Peptide sequence from Human Sestrin-2 protein (42-61AA)

Immunogen Species: Homo sapiens (Human)

Applications: ELISA, IF

Tested Applications: ELISA, IF; Recommended dilution: IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IF:1:50-1:200

Dilution Ratio3:

Dilution Ratio4:

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Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cardiovascular

Research Areas: Cardiovascular;Cell biology;Metabolism