SESN2 Antibody, Biotin conjugated | CSB-PA021096ND01HU

SESN2 Antibody, Biotin conjugated | CSB-PA021096ND01HU | Cusabio

SESN2 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: SESN2

Aliases: Sestrin-2 (EC 1.11.1.15) (Hypoxia-induced gene), SESN2, Hi95 SEST2

Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190) . Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190) . This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615) . May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085) . May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468) . Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684) . Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503) . However, this could not be confirmed (PubMed:19113821) .

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: P58004

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Peptide sequence from Human Sestrin-2 protein (42-61AA)

Immunogen Species: Homo sapiens (Human)

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cardiovascular

Research Areas: Cardiovascular;Cell biology;Metabolism