SESN1 Antibody | CSB-PA021095LA01HU

SESN1 Antibody | CSB-PA021095LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: SESN1

Aliases: Sestrin-1 (EC 1.11.1.15) (p53-regulated protein PA26), SESN1, PA26 SEST1

Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471) . This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity) . May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085) . May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity) . Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503) . However, this could not be confirmed (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q9Y6P5

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Recombinant Human Sestrin-1 protein (224-337AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:5000

Dilution Ratio3: IHC:1:20-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Cell biology;Metabolism