SEM1 Antibody, Biotin conjugated | CSB-PA021263LD01HU

SEM1 Antibody, Biotin conjugated | CSB-PA021263LD01HU | Cusabio

SEM1 Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: SEM1

Aliases: 26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein), SEM1, C7orf76 DSS1 SHFDG1 SHFM1

Background: Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943) . Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388) . The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket) . TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: P60896

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Cell biology