Recombinant Rat Type-2 angiotensin II receptor (Agtr2) , partial | CSB-EP001466RA

Recombinant Rat Type-2 angiotensin II receptor (Agtr2) , partial | CSB-EP001466RA | Cusabio

Alternative Name(s): Angiotensin II type-2 receptor ;AT2

Gene Names: Agtr2

Research Areas: Others

Organism: Rattus norvegicus (Rat)

AA Sequence: MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLE

Source: E.coli

Tag Info: N-terminal GST-tagged

Expression Region: 1-45aa

Sequence Info: Extracellular Domain

MW: 31.9 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation .

Reference: Reversible inactivation of AT(2) angiotensin II receptor from cysteine-disulfide bond exchange.Feng Y.H., Saad Y., Karnik S.S.FEBS Lett. 484:133-138(2000)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (By similarity).

Involvement in disease:

Subcellular Location: Cell membrane, Multi-pass membrane protein

Protein Families: G-protein coupled receptor 1 family

Tissue Specificity: Abundant expression in fetal tissues, immature brain, skin wound and atretic ovarian follicles.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P35351

HGNC Database Link: N/A

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: N/A