Cusabio Mycobacterium tuberculosis Recombinants
Recombinant Mycobacterium tuberculosis 6KDA early secretory antigenic target (esxA), partial | CSB-YP358627MVZ
- SKU:
- CSB-YP358627MVZ
- Availability:
- 25 - 35 Working Days
Description
Recombinant Mycobacterium tuberculosis 6KDA early secretory antigenic target (esxA), partial | CSB-YP358627MVZ | Cusabio
Alternative Name(s): ESAT-6
Gene Names: esxA
Research Areas: Others
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
AA Sequence: WNFAGIEAAASAIQGNVTSIHSLLDEGKQSLTKLAAAWGGSGSEAYQGVQQKWDATATELNNALQNLARTISEAGQAMASTEGNVTGMFA
Source: Yeast
Tag Info: N-terminal 6xHis-tagged
Expression Region: 6-95aa
Sequence Info: Partial
MW: 11.3 kDa
Purity: Greater than 90% as determined by SDS-PAGE.
Relevance: Not known. Elicits high level of IFN-gamma from mory effector cells during the first phase of a protective immune response.
Reference: Mutually dependent secretion of proteins required for mycobacterial virulence.Fortune S.M., Jaeger A., Sarracino D.A., Chase M.R., Sassetti C.M., Sherman D.R., Bloom B.R., Rubin E.J.Proc. Natl. Acad. Sci. U.S.A. 102:10676-10681(2005)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: A secreted protein that plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm. Acts as a strong host (human) T-cell antigen
Involvement in disease:
Subcellular Location: Secreted, Secreted, cell wall, Host cell surface, Host cytoplasm, Host endoplasmic reticulum, Host cell membrane
Protein Families: WXG100 family, ESAT-6 subfamily
Tissue Specificity:
Paythway:
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P9WNK7
HGNC Database Link: N/A
UniGene Database Link: N/A
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: N/A