Recombinant Mouse Angiopoietin-like protein 8 (Angptl8) | CSB-EP844436MO

Recombinant Mouse Angiopoietin-like protein 8 (Angptl8) | CSB-EP844436MO | Cusabio

Alternative Name(s): Betatrophin1

Gene Names: Angptl8

Research Areas: Others

Organism: Mus musculus (Mouse)

AA Sequence: VRPAPVAPLGGPEPAQYEELTLLFHGALQLGQALNGVYRATEARLTEAGHSLGLYDRALEFLGTEVRQGQDATQELRTSLSEIQVEEDALHLRAEATARSLGEVARAQQALRDTVRRLQVQLRGAWLGQAHQEFETLKARADKQSHLLWALTGHVQRQQREMAEQQQWLRQIQQRLHTAALPA

Source: E.coli

Tag Info: N-terminal 6xHis-tagged

Expression Region: 16-198aa

Sequence Info: Full Length of Mature Protein

MW: 24.5 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels . May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state . According to a report, may act by promoting ANGPTL3 cleavage . According to another study, not required for cleavage of ANGPTL3 .

Reference: A mouse knockout library for secreted and transmembrane proteins.Tang T., Li L., Tang J., Li Y., Lin W.Y., Martin F., Grant D., Solloway M., Parker L., Ye W., Forrest W., Ghilardi N., Oravecz T., Platt K.A., Rice D.S., Hansen G.M., Abuin A., Eberhart D.E. , Godowski P., Holt K.H., Peterson A., Zambrowicz B.P., de Sauvage F.J.Nat. Biotechnol. 28:749-755(2010)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels

Involvement in disease:

Subcellular Location: Secreted

Protein Families: ANGPTL8 family

Tissue Specificity: Expressed in liver and fat. Enriched in white and brown adipose tissues.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q8R1L8

HGNC Database Link: N/A

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: N/A