Recombinant Human Neurocalcin-delta (NCALD) | CSB-EP015510HU

Recombinant Human Neurocalcin-delta (NCALD) | CSB-EP015510HU | Cusabio

Alternative Name(s): NCALD; Neurocalcin-delta

Gene Names: NCALD

Research Areas: Neuroscience

Organism: Homo sapiens (Human)

AA Sequence: GKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNRDGKLSLEEFIRGAKSDPSIVRLLQCDPSSAGQF

Source: E.coli

Tag Info: N-terminal GST-tagged

Expression Region: 1-193aa

Sequence Info: Full Length

MW: 49.1 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Reference: "Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy." Kamiyama M., Kobayashi M., Araki S., Iida A., Tsunoda T., Kawai K., Imanishi M., Nomura M., Babazono T., Iwamoto Y., Kashiwagi A., Kaku K., Kawamori R., Ng D.P., Hansen T., Gaede P., Pedersen O., Nakamura Y., Maeda S. Hum. Genet. 122:397-407(2007)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Involvement in disease:

Subcellular Location:

Protein Families: Recoverin family

Tissue Specificity: Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P61601

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM