Recombinant Human herpesvirus 2 Tegument protein VP22 (UL49), partial | CSB-EP310465HJX(A4)

Recombinant Human herpesvirus 2 Tegument protein VP22 (UL49), partial | CSB-EP310465HJX(A4) | Cusabio

Alternative Name(s): UL49Tegument protein VP22

Gene Names: UL49

Research Areas: Others

Organism: Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)

AA Sequence: QGLAKKLHFSTAPPSPTAPWTPRVAGFNKRVFCAAVGRLAATHARLAAVQLWDMSRPHTDEDLNELLDLTTIRVTVCEGKNLLQRANELVNPDAAQDVDATAAARGRPAGRAAATARAPARSASRPRRPLE

Source: E.coli

Tag Info: N-terminal 6xHis-tagged

Expression Region: 170-300aa

Sequence Info: Partial

MW: 17.9 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network.

Reference: "DNA sequence and genetic content of the HindIII l region in the short unique component of the herpes simplex virus type 2 genome: identification of the gene encoding glycoprotein G, and evolutionary comparisons."McGeoch D.J., Moss H.W.M., McNab D., Frame M.C. J. Gen. Virol. 68:19-38(1987)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network.

Involvement in disease:

Subcellular Location: Virion tegument, Host cytoplasm, Host nucleus, Host Golgi apparatus

Protein Families: Alphaherpesvirinae VP22 tegument protein family

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P89468

HGNC Database Link: N/A

UniGene Database Link: N/A

KEGG Database Link: KEGG

STRING Database Link: N/A

OMIM Database Link: N/A