Recombinant Human Glycerol-3-phosphate dehydrogenase [NAD (+) ], Cytoplasmic domain (GPD1) | CSB-EP009709HU

Recombinant Human Glycerol-3-phosphate dehydrogenase [NAD (+) ], Cytoplasmic domain (GPD1) | CSB-EP009709HU | Cusabio

Alternative Name(s): AI747587; cytoplasmic; EC 1.1.1.8; FLJ26652; G3PD; Gdc-1; Gdc1; Gdp1; Glycerol 3 phosphate dehydrogenase 1; Glycerol 3 phosphate dehydrogenase cytosolic; Glycerol 3 phosphate dehydrogenase soluble; Glycerol-3-phosphate dehydrogenase [NAD+]; Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic; Glycerol-3-phosphate dehydrogenase 1 (soluble); Glycerol-3-phosphate dehydrogenase; Glycerol-3-phosphate dehydrogenase, soluble ; Glycerphosphate dehydrogenase; GPD-C; gpd1; Gpd1 protein; Gpd3; GPDA_HUMAN; Gpdc; GPDH; GPDH-C; Gpdhc; HTGTI; KIAA4010; MGC93453; MGPD; mKIAA4010

Gene Names: GPD1

Research Areas: Signal Transduction

Organism: Homo sapiens (Human)

AA Sequence: MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM

Source: E.coli

Tag Info: N-terminal 6xHis-SUMO-tagged

Expression Region: 1-349aa

Sequence Info: Full Length

MW: 53.6 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance:

Reference: A compound heterozygous mutation in GPD1 causes hepatomegaly, steatohepatitis, and hypertriglyceridemia.Joshi M., Eagan J., Desai N.K., Newton S.A., Towne M.C., Marinakis N.S., Esteves K.M., De Ferranti S., Bennett M.J., McIntyre A., Beggs A.H., Berry G.T., Agrawal P.B.Eur. J. Hum. Genet. 22:1229-1232(2014)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function:

Involvement in disease: Hypertriglyceridemia, transient infantile (HTGTI)

Subcellular Location: Cytoplasm

Protein Families: NAD-dependent glycerol-3-phosphate dehydrogenase family

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P21695

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM