Recombinant Human Beta-defensin 4A protein (DEFB4A) (Active) | CSB-AP003041HU

Recombinant Human Beta-defensin 4A protein (DEFB4A) (Active) | CSB-AP003041HU | Cusabio

Protein Description: Full Length of Mature Protein

Alternative Name (s) : Beta-defensin 2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1

Gene Names: DEFB4A,DEFB102,DEFB2,DEFB4;,DEFB4B

Research Areas: Microbiology

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 24-64aa

Sequence Info: GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using immature human dendritic cells is in a concentration range of 10-100 ng/ml.

MW: 4.3 kDa

Purity: >98% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Has antibacterial activity. {ECO:0000305}.

PubMed ID: 9202117; 9831658; 10603376; 10837369; 15489334; 12010514; 10906336; 11714914

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells

Involvement in disease:

Subcellular Location: Secreted

Protein Families: Beta-defensin family, LAP/TAP subfamily

Tissue Specificity: Expressed in the skin and respiratory tract.

Paythway:

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 130 mM NaCl

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: O15263

Uniprot Entry Name: DFB4A_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM