Recombinant Human Beta-catenin-interacting protein 1 (CTNNBIP1) | CSB-EP873645HU

Recombinant Human Beta-catenin-interacting protein 1 (CTNNBIP1) | CSB-EP873645HU | Cusabio

Alternative Name(s): Inhibitor of beta-catenin and Tcf-4

Gene Names: CTNNBIP1

Research Areas: Signal Transduction

Organism: Homo sapiens (Human)

AA Sequence: MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ

Source: E.coli

Tag Info: N-terminal GST-tagged

Expression Region: 1-81aa

Sequence Info: Full Length

MW: 36.2 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

Reference: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

Involvement in disease:

Subcellular Location: Cytoplasm, Nucleus

Protein Families: CTNNBIP1 family

Tissue Specificity:

Paythway: Wntsignalingpathway

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q9NSA3

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM