Recombinant Human 40S ribosomal protein SA (RPSA) | CSB-BP020485HU

Recombinant Human 40S ribosomal protein SA (RPSA) | CSB-BP020485HU | Cusabio

Alternative Name(s): 37 kDa laminin receptor precursor Short name: 37LRP 37/67 kDa laminin receptor Short name: LRP/LR 67 kDa laminin receptor Short name: 67LR Colon carcinoma laminin-binding protein Laminin receptor 1 Short name: LamR Laminin-binding protein precursor p40 Short name: LBP/p40 Multidrug resistance-associated protein MGr1-Ag NEM/1CHD4 Small ribosomal subunit protein uS2 LAMBR, LAMR1

Gene Names: RPSA

Research Areas: Cardiovascular

Organism: Homo sapiens (Human)

AA Sequence: SGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS

Source: Baculovirus

Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-tagged

Expression Region: 2-295aa

Sequence Info: Full Length of Mature Protein

MW: 76.7 kDa

Purity: Greater than 85% as determined by SDS-PAGE.

Relevance: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.

Reference: "Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein." Yow H., Wong J.M., Chen H.S., Lee C., Steele G.D. Jr., Chen L.B. Proc. Natl. Acad. Sci. U.S.A. 85:6394-6398(1988)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.

Involvement in disease: Asplenia, isolated congenital (ICAS)

Subcellular Location: Cell membrane, Cytoplasm, Nucleus

Protein Families: Universal ribosomal protein uS2 family

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P08865

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM