QKI Antibody | CSB-PA842739ESR2HU

QKI Antibody | CSB-PA842739ESR2HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: QKI

Aliases: Protein quaking (Hqk) (HqkI), QKI, HKQ

Background: RNA-binding protein that plays a central role in myelinization (PubMed:16641098) . Binds to the 5'-NACUAAY-N (1, 20) -UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077) . In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098) . Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q96PU8

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Protein quaking protein (1-341AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Purification Method: Antigen Affinity Purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:1000-1:5000

Dilution Ratio3: IHC:1:20-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Neuroscience

Research Areas: Epigenetics & Nuclear Signaling;Neuroscience;Signal transduction