PTPN22 Antibody | CSB-PA019036LA01HU

PTPN22 Antibody | CSB-PA019036LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: PTPN22

Aliases: Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP), PTPN22, PTPN8

Background: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643) . Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704) . Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343) . Dephosphorylates the immune system activator SKAP2 (PubMed:21719704) . Positively regulates toll-like receptor (TLR) -induced type 1 interferon production (PubMed:23871208) . Promotes host antiviral responses mediated by type 1 interferon (By similarity) . Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q9Y2R2

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Tyrosine-protein phosphatase non-receptor type 22 protein (1-179AA)

Immunogen Species: Homo sapiens (Human)

Applications: ELISA, IF

Tested Applications: ELISA, IF; Recommended dilution: IF:1:200-1:500

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IF:1:200-1:500

Dilution Ratio3:

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal transduction