Renin-Angiotensin System in the Pancreas

Raffaele Pezzilli
Emergency Department, Sant’Orsola Hospital. Bologna, Italy
The findings that a local renin-angiotensin
system (RAS) exists in the pancreas and its
relevance in the regulation of pancreatic
microcirculation and ductal anion secretion
have been well described by Leung [1].
Furthermore, the significance of the activation
of pancreatic RAS by chronic hypoxia and
acute pancreatitis has been discussed in detail
by Nobiling [2], Lai [3], and by Ip and
coworkers [4]. The role of the RAS in the
disease involving the endocrine and exocrine
pancreas has been critically reported by
Carlsson [5], Chappell [6] and Lam [7]. In
particular, the effects of food components on
the pancreatic RAS have been pointed out by
Grant [8] and a critical appraisal of the
intrinsic pancreatic angiotensin-generating
system has been proposed by Sernia [9].
The RAS represents a new opportunity to
better understand the mechanisms involved in
the acute and chronic diseases of the exocrine
and endocrine pancreas and, in the near
future, it is possible that new therapeutic
procedures which use this knowledge will be
employed in clinical practice; in fact, all the
authors suggested a clinical perspective for
future basic and clinical studies.
I am convinced that the entire group of
authors has satisfied both my desire, and that
the Guest Editor produces a concise and
informative round table.
I am grateful to all the authors for the care
with which they prepared their manuscripts
since it is with papers such as these that we
maintain the excellence of our Journal; in
particular, we thank Po Sing Leung for his
interest and hard work in organizing and
coordinating this first virtual round table for
JOP, Journal of the Pancreas.
I hope many readers will be stimulated by
these contributions. In most cases, the use of
this knowledge in clinical practice will
require careful attention and I hope that, in the
near future, there will be a feedback regarding
this important research.
Finally, the topics have not only been
addressed to researchers but also to those who
while in training are developing a special
interest in the pancreas and I am sure that
trainees in the field of pancreatology will take
this knowledge into consideration in their
future professional work.
The seed has been sown; now we are waiting
for it to take root.
Raffaele Pezzilli
Emergency Department
Sant’Orsola Hospital
Via G. Massarenti, 9
40138 Bologna
1. Leung PS. Local renin-angiotensin system in the
pancreas: the significance of changes by chronic
hypoxia and acute pancreatitis. JOP J Pancreas

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JOP. J. Pancreas (Online) 2001; 2(1):56-57.
JOP – Journal of the Pancreas - - Vol.2, No. 1 January 2001
(Online) 2001; 2:3-8.
2. Nobiling R. Renin-angiotensin system: from the
renal basis to an organ-specific subsystem in pancreas.
JOP J Pancreas (Online) 2001; 2:9-12.
3. Lai PBS. Local renin-angiotensin system in the
pancreas: the significance in acute pancreatitis. JOP J
Pancreas (Online) 2001; 2:13-15.
4. Ip SP, Che CT, Leung PS. Association of free
radicals and tissue renin-angiotensin system:
prospective effects of Rhodiola, a genus of Chinese
herb, on hypoxia-induced pancreatic injury. JOP J
Pancreas (Online) 2001; 2:16-25.
5. Carlsson PO. The renin-angiotensin system in the
endocrine pancreas. JOP J Pancreas (Online) 2001;
6. Chappell MC, Diz DI, Gallagher PE. The renin-
angiotensin system and the exocrine pancreas. JOP J
Pancreas (Online) 2001; 2:33-39.
7. Lam KY. Pancreatic renin-angiotensin system: is
there a role in endocrine oncology?. JOP J Pancreas
(Online) 2001; 2:40-42.
8. Grant G. Possible involvement of the local renin-
angiotensin system in exocrine pancreas responses to
food components. JOP J Pancreas (Online) 2001; 2:43-
9. Sernia C. A critical appraisal of the intrinsic
pancreatic angiotensin-generating system. JOP J
Pancreas (Online) 2001; 2:50-55

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