POLI Antibody, Biotin conjugated | CSB-PA892157LD01HU

POLI Antibody, Biotin conjugated | CSB-PA892157LD01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: POLI

Aliases: DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B), POLI, RAD30B

Background: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: Q9UNA4

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human DNA polymerase iota protein (458-711AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling