Cusabio Polyclonal Antibodies
PKM Antibody | CSB-PA143103
- SKU:
- CSB-PA143103
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
PKM Antibody | CSB-PA143103 | Cusabio
PKM Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Product Type: Polyclonal Antibody
Target Names: PKM
Aliases: PKM; PK3; OIP3; PK2;
Background:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Christofk, H.R. et al. (2008) Nature 452, 230-3.
Mazurek, S. et al. (2005) Semin Cancer Biol 15, 300-8.
Dombrauckas, J.D. et al. (2005) Biochemistry 44, 9417-29.
Hitosugi, T. et al. (2009) Sci Signal 2, ra73.
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: P14618
Host Species: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Peptide sequence around aa. 399~403 (V-R-A-S-S) derived from Human PKM1.
Immunogen Species: Human
Applications: ELISA, WB, IF
Tested Applications: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200
Purification Method: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:1000
Dilution Ratio3: IF:1:100-1:200
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Signal Transduction
Research Areas: Epigenetics & Nuclear Signaling;Cancer;Metabolism;Signal transduction