PKD1 Antibody | CSB-PA23149A0Rb

PKD1 Antibody | CSB-PA23149A0Rb | Cusabio

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Product Type: Polyclonal Antibody

Target Names: PKD1

Aliases: Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein), PKD1

Background: Involved in renal tubulogenesis (PubMed:12482949) . Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity) . Acts as a regulator of cilium length, together with PKD2 (By similarity) . The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity) . The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity) . May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P98161

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Polycystin-1 protein (615-753AA)

Immunogen Species: Human

Applications: ELISA, IHC, IF

Tested Applications: ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:500-1:1000

Dilution Ratio3: IF:1:200-1:500

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Cancer;Metabolism;Signal transduction