Phospho-SMAD3 (Thr179) Antibody | CSB-PA905682

Phospho-SMAD3 (Thr179) Antibody | CSB-PA905682 | Cusabio

Phospho-SMAD3 (Thr179) Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: SMAD3

Aliases: JV15-2; MAD-3; MADH3; Smad 3; Mothers against decapentaplegic homolog 3

Background:

Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Cohen-Solal KA, et al. (2011) Pigment Cell Melanoma Res 24, 512-24
Zelivianski S, Cooley A, Kall R, Jeruss JS (2010) Mol
Cancer Res 8, 1375-87
Matsuura I, et al. (2010) J Biol Chem 285, 1754-64

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P84022

Host Species: Rabbit

Species Reactivity: Human, Mouse, Rat

Immunogen: Peptide sequence around phosphorylation site of threonine179 (P-E-T (p) -P-P) derived from Human Smad3 .

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:1000

Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Epigenetics & Nuclear Signaling;Cancer;Metabolism;Signal transduction;Stem cells