Cusabio Recombinant Antibodies
Phospho-RPA2 (T21) Antibody | CSB-RA020089A21phHU
- SKU:
- CSB-RA020089A21phHU
- Availability:
- 3 to 7 Working Days
Description
Phospho-RPA2 (T21) Antibody | CSB-RA020089A21phHU | Cusabio
Phospho-RPA2 (T21) Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Antibody Type: Recombinant Antibody
Target Names: RPA2
Aliases: Replication protein A 32 kDa subunit, Replication factor A protein 2, RF-A protein 2, Replication protein A 34 kDa subunit, RP-A p34, RPA2, REPA2, RPA32, RPA34
Background: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Isotype: Rabbit IgG
Conjugate: Non-conjugated
Clonality: Monoclonal
Clone Number: 3B2
Uniport ID: P15927
Modified: Epigenetics and Nuclear Signaling
species: Human
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human Phospho-RPA2 (T21)
Tested Applications: ELISA, IF; Recommended dilution: IF:1:20-1:200
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.