Cusabio Polyclonal Antibodies
Phospho-FADD (Ser191) Antibody | CSB-PA446731
- SKU:
- CSB-PA446731
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
Phospho-FADD (Ser191) Antibody | CSB-PA446731 | Cusabio
Phospho-FADD (Ser191) Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: FADD
Aliases: MORT1 ; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity;
Background:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Sugano S., Nat. Genet. 36:40-45 (2004) .
Farmer A., Submitted (MAY-2003) .
Venter J.C., Submitted (JUL-2005) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: Q13158
Host Species: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Peptide sequence around phosphorylation site of Serine191 (R-S-G (p) -A-M) derived from Human FADD.
Immunogen Species: Human
Applications: ELISA, WB, IHC
Tested Applications: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100
Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:1000
Dilution Ratio3: IHC:1:50-1:100
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Cell Biology
Research Areas: Cancer;Cell biology