Phospho-CDKN1A (Thr145) Antibody | CSB-PA074462

Phospho-CDKN1A (Thr145) Antibody | CSB-PA074462 | Cusabio

Phospho-CDKN1A (Thr145) Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: CDKN1A

Aliases: CAP20; CDK-interacting protein 1; CDKN1; CDKN1A; CDN1A

Background: May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

Ocker M Int, et al. (2007) J Biochem Cell Biol. 39 (7-8) :1367-74.
Dangi S, et al. (2006) Cell Prolif. 39 (4) :261-79.
Chen J, et al. (2006) Am J Physiol Heart Circ Physiol. 290 (4) :H1575-86

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P38936

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Peptide sequence around phosphorylation site of threonine 145 (R-Q-T (p) -S-M) derived from Human p21Cip1.

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC;IHC:1:50-1:100

Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:50-1:100

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Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Epigenetics & Nuclear Signaling;Cancer;Cell biology