NRP1 Antibody | CSB-PA016091ESR1HU

NRP1 Antibody | CSB-PA016091ESR1HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: NRP1

Aliases: Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304), NRP1, NRP VEGF165R

Background: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O14786

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Neuropilin-1 protein (684-923AA)

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Purification Method: Antigen Affinity purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

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Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cardiovascular

Research Areas: Neuroscience;Cardiovascular;Immunology