NANOG Antibody, HRP conjugated | CSB-PA888008LB01HU

NANOG Antibody, HRP conjugated | CSB-PA888008LB01HU | Cusabio

NANOG Antibody, HRP conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: NANOG

Aliases: Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog), NANOG

Background: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Isotype: IgG

Conjugate: HRP

Clonality: Polyclonal

Uniport ID: Q9H9S0

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Homeobox protein NANOG protein (1-305AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Stem Cells

Research Areas: Epigenetics & Nuclear Signaling;Cancer;Developmental biology;Stem cells