MSH6 Monoclonal Antibody | CSB-MA0150321A0m

MSH6 Monoclonal Antibody | CSB-MA0150321A0m | Cusabio

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Product Type: Monoclonal Antibody

Target Name: MSH6

Aliases: MutS Homolog 6, GTBP, HSAP2, DNA Mismatch Repair Protein Msh6, G/T Mismatch-Binding Protein

Relevance: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have beendescribed.

Isotype: IgG

Conjugate: Non-conjugated

Clone Number: 2C12F3

Uniport ID: P52701

Alternatives To SCBT: sc-137015/sc-271979

Host Species: Mouse

Species Reactivity: Human

Immunogen: Recombinant Human MSH6 Protein

Immunogen Species: Human

Applications: ELISA, IHC

Tested Applications: ELISA, IHC;Recommended dilution:IHC:1:50-1:500

Purification Method: >95%, Protein G purified

Dilution Ratio1: IHC:1:50-1:500

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics and Nuclear Signaling