Cusabio Polyclonal Antibodies
MERTK Antibody | CSB-PA253602
- SKU:
- CSB-PA253602
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
MERTK Antibody | CSB-PA253602 | Cusabio
MERTK Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Product Type: Polyclonal Antibody
Target Names: MERTK
Aliases: C-mer; kinase Mer; MERK; MERTK; proto-oncogene tyrosine-protein kinase MER precursor
Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis) . Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs) -mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Graham D.K., Cell Growth Differ. 5:647-657 (1994) .
Gal A., Nat. Genet. 26:270-271 (2000) .
Hillier L.W., Nature 434:724-731 (2005) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: Q12866
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Synthesized peptide derived from N-terminal of human MERTK.
Immunogen Species: Human
Applications: ELISA, WB
Tested Applications: ELISA, WB;WB:1:500-1:3000
Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:3000
Dilution Ratio3:
Dilution Ratio4:
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Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Neuroscience
Research Areas: Neuroscience;Signal transduction