LRP8 Antibody, HRP conjugated | CSB-PA623900LB01HU

LRP8 Antibody, HRP conjugated | CSB-PA623900LB01HU | Cusabio

LRP8 Antibody, HRP conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: LRP8

Aliases: Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2), LRP8, APOER2

Background: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE) -containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP) . Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.

Isotype: IgG

Conjugate: HRP

Clonality: Polyclonal

Uniport ID: Q14114

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Low-density lipoprotein receptor-related protein 8 protein (131-332AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Neuroscience

Research Areas: Neuroscience;Cancer;Cardiovascular;Metabolism;Signal transduction