GLIS2 Antibody, Biotin conjugated | CSB-PA861185LD01HU

GLIS2 Antibody, Biotin conjugated | CSB-PA861185LD01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: GLIS2

Aliases: Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein), GLIS2, NKL

Background: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity) . Represses the Hedgehog-dependent expression of Wnt4 (By similarity) . Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity) . Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity) .

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: Q9BZE0

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Zinc finger protein GLIS2 protein (332-505AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling;Neuroscience;Signal transduction;Stem cells