Cusabio Polyclonal Antibodies
FHIT Antibody | CSB-PA11547A0Rb
- SKU:
- CSB-PA11547A0Rb
- Availability:
- 3 to 7 Working Days
Description
FHIT Antibody | CSB-PA11547A0Rb | Cusabio
FHIT Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: FHIT
Aliases: Bis (5'-adenosyl) -triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Diadenosine 5', 5'''-P1, P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein), FHIT
Background: Cleaves P1-P3-bis (5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P1-P4-bis (5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P1-P3-bis (5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: P49789
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Bis (5'-adenosyl) -triphosphatase protein (2-147AA)
Immunogen Species: Human
Applications: ELISA, IHC, IF
Tested Applications: ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:500
Purification Method: >95%, Protein G purified
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: IHC:1:500-1:1000
Dilution Ratio3: IF:1:50-1:500
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Epigenetics and Nuclear Signaling
Research Areas: Epigenetics & Nuclear Signaling;Cancer