CPEB4 Antibody | CSB-PA618177LA01HU

CPEB4 Antibody | CSB-PA618177LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: CPEB4

Aliases: Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4), CPEB4, KIAA1673

Background: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967) . RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967) . Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity) . Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195) . Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752) . Stimulates proliferation of melanocytes (PubMed:27857118) . In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q17RY0

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 protein (244-515AA)

Immunogen Species: Human

Applications: ELISA, WB, IF

Tested Applications: ELISA, WB, IF; Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:1000-1:5000

Dilution Ratio3: IF:1:50-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling