CPEB3 Antibody | CSB-PA818773LA01HU

CPEB3 Antibody | CSB-PA818773LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: CPEB3

Aliases: Cytoplasmic polyadenylation element-binding protein 3, CPE-BP3, CPE-binding protein 3, hCPEB-3, CPEB3, KIAA0940

Background: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity) . In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity) . Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity) . In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity) . Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity) . When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity) . In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity) . Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity) . Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity) . Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257) . In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532) . In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q8NE35

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Cytoplasmic polyadenylation element-binding protein 3 protein (414-525AA)

Immunogen Species: Human

Applications: ELISA, IF

Tested Applications: ELISA, IF; Recommended dilution: IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IF:1:50-1:200

Dilution Ratio3:

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Neuroscience

Research Areas: Neuroscience