Cusabio Polyclonal Antibodies
CIITA Antibody | CSB-PA349864
- SKU:
- CSB-PA349864
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
CIITA Antibody | CSB-PA349864 | Cusabio
CIITA Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: CIITA
Aliases: MHC class II transactivator; CIITA; CIITA; MHC2TA;
Background: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) .
Steimle V., Cell 75:135-146 (1993) .
Al-Kandari W., J. Mol. Biol. 369:1175-1187 (2007) .
Al-Kandari W., Mol. Immunol. 44:311-321 (2007) .
Croager E.J., Biochim. Biophys. Acta 1353:231-235 (1997) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: P33076
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from internal of human CIITA.
Immunogen Species: Human
Applications: ELISA, WB
Tested Applications: ELISA, WB;WB:1:500-1:3000
Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:3000
Dilution Ratio3:
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Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Immunology
Research Areas: Epigenetics & Nuclear Signaling;Immunology