CBR1 Antibody | CSB-PA047884

CBR1 Antibody | CSB-PA047884 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: CBR1

Aliases: 15-hydroxyprostaglandin dehydrogenase [NADP+]; 2; 9-reductase; carbonyl reductase (NADPH) ; carbonyl reductase (NADPH) 1

Background: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Wermuth B., J. Biol. Chem. 263:16185-16188 (1988) .
Forrest G.L., Biochim. Biophys. Acta 1048:149-155 (1990) .
Forrest G.L., Mol. Pharmacol. 40:502-507 (1991) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P16152

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Synthesized peptide derived from internal of human CBR1.

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

Dilution Ratio3: IHC:1:50-1:100

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Cancer;Cell biology;Metabolism;Signal transduction