CASP10 Antibody | CSB-PA072389

CASP10 Antibody | CSB-PA072389 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: CASP10

Aliases: ALPS2; CASP10B; FLICE2; Caspase 10 isoform a preproprotein; Caspase 10 isoform b preproprotein

Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform C is proteolytically inactive.

Frank C. Kischkel, J. Biol. Chem., Nov 2001; 276: 46639 - 46646.
Ingo H. Engels, Mol. Cell. Biol., Apr 2005; 25: 2808 - 2818.
Daniela Sciaky, J. Immunol., Apr 2000; 164: 3806.
Jin Wang, PNAS, Nov 2001; 98: 13884.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q92851

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Synthesized peptide derived from human Caspase 10.

Immunogen Species: Human

Applications: ELISA, WB, IHC, IF

Tested Applications: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

Dilution Ratio3: IHC:1:50-1:100

Dilution Ratio4: IF:1:100-1:500

Dilution Ratio5:

Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Cancer;Cell biology;Metabolism