APC Antibody | CSB-RA951649A0HU

APC Antibody | CSB-RA951649A0HU | Cusabio

APC Antibody is Available at Gentaur Genprice with the fastest delivery.

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Antibody Type: Recombinant

Target Names: APC

Aliases: Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5), APC, DP2.5

Background: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Isotype: Rabbit IgG

Conjugate: Non-conjugated

Clonality: Monoclonal

Clone Number: 5F2

Uniport ID: P25054

Modified: Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cardiovascular; Cell biology; Stem cells

species: Homo sapiens (Human)

Species Reactivity: Human, Rat

Immunogen: A synthesized peptide derived from human APC

Tested Applications: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200

Purification Method: Affinity-chromatography

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.